Nonetheless, patients with hepatitis after mRNA-1273 (n = 12) had more severe histological injury (Ishak necroinflammation grade 11 vs. 9, p = 0.001), higher SMA titers (≥1:160 in 8/8 vs. in 2/8, p = 0.007) and higher pIgG concentrations (median 1.6 vs. 0.9, p = 0.012) than after BNT162b2 (n = 30). This evidence concerns the gene SMN1 and Hepatitis.