Besides, using AVmin ≤ 0 HU as the best threshold to diagnose adenoma, 44 cases (10.92%) and 13 cases (18.31%) of adenoma with CTH negative pixels < 10% could be diagnosed in center A and center B. It should be noted that 4 cases (1.89%) with AVmin ≤ 0 HU were non-adenoma in the two centers, which may be related to sparse visible components (e.g., nucleus) in the stroma of ganglioneuroma, edema in some cases, and small necrotic areas in the measurement of metastatic tumors that could not be distinguished by naked eyes. Here, CTH is linked to adenoma.