Participants in the highest serum Klotho quartile were more likely to be young, female, non-Hispanic Blacks and have higher educational levels, less likely to smoke, drink alcohol, and perform physical activity, more likely to have lower waist circumference, lower levels of TG and creatinine as well as higher levels of LDL-C and HDL-C, and less likely to have dyslipidemia, CVD, and hypertension (all P < 0.05). The gene discussed is KL; the disease is metabolic syndrome.