The overall prevalence of diabetes was 25.9% (n = 3557), which was 27.1% (n = 933), 24.5% (n = 842), 24.7% (n = 850) and 27.1% (n = 932) in serum Klotho quartiles 1-4, respectively (P = 0.01). The gene discussed is KL; the disease is diabetes mellitus.