NF1 and adrenal gland pheochromocytoma: Germline mutations in the neurofibromatosis gene (NF1) belong to Cluster II and account for approximately 3% of all PCC cases (15, 16), while the frequency of somatic mutations in PCC is estimated to be 20-30%; both germline and somatic NF1 mutations have been amply described in PCC (17–19).