TMEM127 and adrenal gland pheochromocytoma: As the patient’s tumor produced both metanephrines and normetanephrines, it was predicted that her tumor belongs to the Cluster II classification in PCC genes associated with kinase signaling including RET, NF1, and TMEM127, as opposed to Cluster I PCC tumors that are associated with pseudohypoxia signaling pathway (21).