Reviewing the results of the positive drug metformin, metformin was found to have a significant effect in reducing LH/FSH and blood lipid biochemical indexes, compared with thiazolidinediones (THIAZOLES), insulin sensitizers are limited to metformin, which has different benefits for patients with PCOS, including improved weight management and glucose tolerance, reduced androgen production, and improved menstrual cycle and fertility (55). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.