For example, upregulation of PVT1 contributes to T1DM induced end-stage renal disease (22).LncRNA XIST serves as a diagnostic biomarker of gestational diabetes and regulates trophoblast cells via miR-497-5p/FOXO1 axis (23).At the same time, KEGG enrichment analysis was conducted for these lncRNA-mRNA interactions (Figure 3C). This evidence concerns the gene FOXO1 and stage 5 chronic kidney disease.