After that, the patient started to experience fluctuating blood glucose with severe hypoglycaemia (Figure 1B), despite tight control of continuous subcutaneous insulin glulisine infusion (0.5U/h, 8-10; 0.25U/h, 10-12; 0.1U/h, 12-15; 0.05U/h, 15-24; 0.05U/h, 5-7) via smart insulin pump (Medtronic, Models MMT-712). The gene discussed is INS; the disease is Hypoglycemia.