In this study, MBCBM patients, like all MBC patients, shared multiple similar clinicopathological characteristics, including age, ethnicity, laterality, ER status, PR status, histological subtype, BC subtype, etc. MBCBM patients, on the other hand, had larger tumors, higher grades, later T/N stages, higher risks of metastasis, higher possibilities of non-surgical treatment, and shorter OS and CSS. The gene discussed is ESR1; the disease is breast cancer.