The AT8 epitope p-tau 202/205/20840 is a marker for NFT and neuritic pathology in the brains of patients with Alzheimer’s disease and mouse models of Alzheimer’s disease.27,41 Like p-tau 217 and p-tau 231, p-tau 202/205/208 (AT8) signals were only detected in the brains of AppNLGF mice as punctate structures around Aβ plaques (Fig. 1C and G). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.