Under pathological conditions, tau proteins can erroneously localize to or be locally translated in the dendrites and postsynapses of the brains of patients with Alzheimer’s disease and mouse models of Alzheimer’s disease.51–55 Brain sections from 24-month-old AppNLGF mice were therefore stained with antibodies against p-tau 202/205/208 (AT8) and microtubule-associated protein 2 (MAP2), a marker for cell bodies and dendrites of mature neurons, or postsynaptic density protein 95 (PSD95), a marker for postsynaptic density. Here, DLG4 is linked to early-onset autosomal dominant Alzheimer disease.