Additionally, macrophages, mast cells, T cells, and NK cells may be associated with inflammatory cell recruitment in CTEPH by regulating the expression of ICAM1 and ITGB2. Moreover, circ_0007400 may contribute to the progression of CTEPH by acting as a competing endogenous RNA to regulate TP53 in cancer stem cells and CRISPLD2+ cells. The gene discussed is CRISPLD2; the disease is chronic thromboembolic pulmonary hypertension.