NPPB and pulmonary arterial hypertension: In the recently released 2022 ESC/ERS guidelines for the diagnosis and treatment of PH (4), the four-strata COMPERA 2.0 model of Hoeper et al. (22) using WHO-FC, 6MWD, and BNP/NT-proBNP is recommended for risk stratification at follow-up to guide treatment strategies in adult patients with PAH.