(3) Cold weather correlated well with thrombus load (Miller index), cardiac function (WHO functional class, NT-proBNP), hemodynamic parameters (heart rate, mPAP, PVR) and abnormal coagulation and fibrinolytic system (D-dimer) in patients with APE; (4) Follow-up analysis demonstrated that APE patients in cold weather had a significantly higher clinical worsening event rate and could be an independent predictor of clinical outcome. This evidence concerns the gene NPPB and apparent mineralocorticoid excess.