The logistic regression analysis of the prediction model (Table 3, Model 2) showed that age, smoking, diabetes, LDL-C, hemoglobin, NT-proBNP, ejection fraction, and rs541 were independent risk factors for ICM and that those with a mutant AT genotype in rs5491 showed a higher frequency of ICM relative to those with the AA genotype (OR: 5.816, 95%CI: 1.661–20.362, P = 0.006). The gene discussed is NPPB; the disease is diabetes mellitus.