Although a previous study (21) found a correlation between the level of soluble ICAM-1 (sICAM-1) and the severity of atherosclerosis and also described that the inhibition of ICAM-1 expression could postpone the progression of atherosclerosis in apolipoprotein E-knockout mice, no study has proved the nomogram of association between the polymorphism of rs5491 in the ICAM-1 gene and coronary artery disease or ICM. Here, APOE is linked to coronary artery disorder.