When we examined the serum lncRNAs; NEAT1, HOTAIR, and GAS5 levels among the three studied groups (CVS + HTN, CVS + NHTN, and controls) we found that there was a higher level of NEAT1 in each case group (median (IQR) = 3.68 (1.35–7.35) for hypertensive group and median (IQR) = 3.05 (0.95–6.45) for the non-hypertensive group when compared to controls, and stroke patients with hypertension had significant higher NEAT1 when compared to stroke patients without hypertension (P = 0.04). Here, HOTAIR is linked to hypertensive disorder.