FOXO1 and periodontitis: A study reported that the newly discovered lncRNA ENST00000446358 (lncRNA-POIR) in PDLSC of patients with periodontitis mutually inhibited miR-182 and regulated the target gene of miR-182, forkhead box protein O1 (FoxO1), Inhibit the Wnt pathway, thereby enhancing the osteogenic effect [68].