However, in the multivariate analysis, age > 60 (HR: 2.086, 95% CI: 1.371–3.175), ECOG > 1 (HR: 2.666, 95% CI: 1.790–3.970), Ann Arbor stage III-IV (HR: 1.857, 95% CI: 1.035–3.333), BM involvement (HR: 2.024, 95% CI: 1.413–2.898), low LMR (HR: 1.605, 95% CI: 1.128–2.283), and low Alb (HR: 1.548, 95% CI: 1.088–2.202) were independent risk factors of OS in patients with DLBCL. The gene discussed is ALB; the disease is diffuse large B-cell lymphoma.