We first silenced GALNT1 expression using shRNA in multiple GC cell lines, including MKN45, SGC7901, and AGS, and discovered that the Wnt/β-catenin signaling-related molecules β-catenin and phospho-β-catenin (S675) had considerably lower levels, as did c-Myc, a downstream target (Fig. 5C-E). Here, MYC is linked to gastric cancer.