Importantly, GALNT1 plays a vital role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin 1 (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 17, 18, 20. The gene discussed is GALNT1; the disease is cancer.