CASP3 and non-small cell lung carcinoma: In primary NSCLC cells (“pCan2” and “pCan3”) and A549 cells, ADCK2 silencing, by ADCK2-sh, significantly augmented the activity of caspase-3 (Figure 4H) and increased the ratio of TUNEL-stained nuclei (Figure 4I), supporting apoptosis induction.