Moreover, CD68+/CD206+ M2 macrophage infiltration positively correlated with adverse clinical outcomes, including depth of invasion (p<0.05), lymph node metastasis (p<0.0001), distant metastasis (p<0.05), Gleason patterns (p<0.0001) and advanced TNM stage (p<0.0001) (Table S1). This evidence concerns the gene CD68 and metastatic malignant neoplasm in the lymph nodes.