TLR2 signaling has been reported to have a protective role in inflammatory conditions (Lowe et al., 2010; Brun et al., 2013) and colorectal cancer (Sittipo et al., 2018), and to promote immune homeostasis by inhibiting the expression of pro-inflammatory cytokines and enhancing IL-10 production (Chang et al., 2017). Here, IL10 is linked to colorectal cancer.