In a mouse model of dextran sodium sulfate-induced colitis, treatment with a thiazolidinedione, which is a PPAR-γ agonist, reduced colonic inflammation via NFκB-dependent (Takaki et al., 2006; Simeoli et al., 2016) and myosin light-chain kinase-dependent mechanisms (Zhao et al., 2018). The gene discussed is NFKB1; the disease is colitis.