A previous study has reported a link between PPAR-γ and colonic inflammation in CDI by establishing an animal model of CDI using wild-type (WT) mice and T cell-specific PPAR-γ null mice, and showed that the loss of PPAR-γ in T cells increased disease severity and colonic inflammation in the mice with CDI (Viladomiu et al., 2012). This evidence concerns the gene PPARG and clostridium difficile infection.