At the same time, mouse serum OVA-sIgE, total IgE, IL-4, and IL-5 levels, along with H&E staining of nasal tissue, showed that gut microbiota dysbiosis dysregulates Th2 type allergic reaction and nasal inflammation in AR mice, which is consistent with previous studies of other allergic diseases (Yang et al., 2019; Kim et al., 2020). The gene discussed is IGHE; the disease is allergic disease.