For example, in a nude mouse experiment, PAB inhibits gastric cancer cell lung metastasis, inducing cell apoptosis by suppressing phosphatidylinositol-4,5-bisphosphate 3-kinases and protein kinase B (PI3K/Akt), ERK1/2 and mitochondrial signaling pathways (Wang D. et al., 2017). This evidence concerns the gene AKT1 and gastric cancer.