TLR7 and systemic lupus erythematosus: Upon Comparing CG genotype of TLR7-rs3853839 to the wild genotype CC, significant difference was found (P value = 0.04, OR 0.53, CI 95% 0.30 to 0.98) also, the G-allele of TLR7-rs3853839 was associated with SLE occurrence in our study (G/C, P = 0.01, OR 0.55, 95% CI 0.34 to 0.89).