TLR7 and systemic lupus erythematosus: In accordance with our study (Wang et al., 2019), stated that TLR7 rs3853839 C/G SNP was associated with more severe disease (high SLEDAI score where P value = 0.02); they claimed that this association was a result of higher TLR7 expression in SLE patients caused by an upregulation of IFN-responsive genes which this SNP stimulated.