Moreover, since Beclin-1 is localized primarily within cytoplasmic structures, including the ER, mitochondria and the perinuclear membrane [43], and we observed T2DM-induced changes in the architectonics of these cell structures, it would be interesting to juxtapose it with the fluctuations of Beclin-1 protein level. The gene discussed is BECN1; the disease is type 2 diabetes mellitus.