The administration of the studied substances may have the possible anti-apoptotic and neuroprotective effects, that are expressed in diminishing caspase-3 level after metformin (by 8.8 times), after PA treatment (by 1.94 times), and expectedly when their action was combined – by 2.93 folds vs. T2DM. The gene discussed is CASP3; the disease is type 2 diabetes mellitus.