Metformin administration led to a slight elevation of Bcl-xl protein content compared with the T2DM group, however, PA alone and PA together with metformin exerted more pronounced increasing effects on the expression of Bcl-xl protein, which was even higher than in the VMH of the control animals (by 14% and 67% vs. respectively). This evidence concerns the gene BCL2L1 and type 2 diabetes mellitus.