In contrast, PA administration reduced Bax mRNA level compared with the T2DM rats by 1.81 times (Figure 4d), therefore, when we studied the combined treatment, we observed the compensation of an increasing effect of metformin on Bax content and a decreasing action of PA, resulted in the Bax levels that was relative those in the control and the T2DM groups. Here, BAX is linked to type 2 diabetes mellitus.