In conclusion, this study constructed and validated a 2-gene oxidative stress-related LUAD prognostic model, MAP3K19 and NTSR1, which were significantly correlated with clinical variables (including LUAD pathological stage and TNM grade) and significantly affected the infiltration of immune cells in the tumor microenvironment (TME) of LUAD. The gene discussed is MAP3K19; the disease is neoplasm.