HCC: hepatocellular carcinoma; NI: normal interval; PT: prothrombin time; INR: international normalized ratio; AST: aspartate aminotransferase; ALT: alanine transaminase; PLT: platelets; AFP: alpha-fetoprotein; MELD: model for end-stage liver disease; HAV: hepatitis A virus; HBV: hepatitis B virus; HCV: hepatitis C virus. The gene discussed is F2; the disease is hepatocellular carcinoma.