TDP-43 proteinopathies can appear as a range of phenotypes from ALS to FTLD and within that range there is an association of TDP-43 gene mutations that result in certain phenotypes of Parkinsonism, with the similar pathology of mislocalization and dysfunction of TDP-43 translocation back to the nucleus like in other neurodegenerative diseases [37]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.