Recently identified splicing factor proline/glutamine (SFPQ) in ALS pathogenesis and FUS interaction was altered in neurons containing TDP-43 aggregates in progressive supranuclear palsy, FTD, and ALS, and SFPQ expression were shown to be depleted in the same diseases, but not shown in AD, FTD, and globular glial tauopathy [44]. Here, SFPQ is linked to Alzheimer disease.