It was found that granulin precursor (GRN), Transmembrane protein 106B (TMEM106B), ATP Binding Cassette Subfamily C Member 9 (ABCC9), and APOE had significant gene association with pathology leading to LATE phenotypes and hippocampal sclerosis [39,40]. GRN, TMEM106B, and ABCC9 showed a change in expression when manipulating TDP-43 proteinopathy and APOE was shown to link AD to pathological changes [39,40]. This evidence concerns the gene TARDBP and Alzheimer disease.