TCGA analysis demonstrated that the expression levels of CDK1, CCNB1, CCNA2, TOP2A, BUB1, AURKB, CCNB2, BUB1B, NCAPG, and KIF11 were significantly elevated in the patients with HCC (p < 0.05; Figure 9) and associated with the disease-free progression and overall survival (OS) of HCC patients (Figures 10 and 11). This evidence concerns the gene TOP2A and hepatocellular carcinoma.