Zhang X used four routinely detected variables, namely carcinoembryonic antigen (CEA) levels, monocyte counts, N-terminal parent-B natriuretic peptide (NT-pro-BNP) levels, and pleural effusion chloride levels at admission as predictors and developed the CONCH prognostic scoring system, which can guide the choice of malignant pleural effusion (MPE) interventions and management (26). The gene discussed is NPPB; the disease is Pleural effusion.