BRCA1 and cancer: Currently, the principles of BRCA mutation detection in China mainly refers to the guideline on next-generation sequencing-based BRCA1/2 testing (2019) (11), the US National Comprehensive Cancer Network (NCCN) guidelines (87) and the European Society of Medical Oncology (ESMO) guidelines (88), as well as other Chinese expert consensus on specific cancers or genetic testing (summarized in Table 2).