In a study by Pierini (42), mice bearing subcutaneous CT26 colorectal or TC1 lung tumors were treated with heterologous TEM1 (a protein expressed in the tumor-associated endothelium and/or stroma of various types of cancer) -based vaccine, in combination with RT, and PD-L1 antibody or combinations of these therapies. The gene discussed is CD274; the disease is cancer.