EGFR ligands that bind to their receptors mediate downstream signaling pathways, including RAS (rat sarcoma)/RAF (rapidly accelerating fibrosarcoma), phosphatidylinositol 3-kinase (PI3K)/AKT (the serine/threonine protein kinase) pathway contributes to lung tumor growth and metastasis (5). This evidence concerns the gene AKT1 and fibrosarcoma.