M2 type TAM-derived exosomes also contribute to irreversible tyrosine kinase inhibitor (TKI) of EGFR, osimertinib resistance in NSCLC by modulating the MSTRG.292666.16/miR-6386-5p/MAPK8IP3 axis (23). This evidence concerns the gene EGFR and non-small cell lung carcinoma.