IFNG and cardiac arrhythmia: Moreover, it was also reported that IL-2 led to the destruction of cells and neurons, fibrosis, and blockage of the cardiac conduction system, which favors arrhythmia by predisposing to reentrant tachycardias (56), and that IFN-γ was related to increased release of severe cardiac disorders by causing endothelial injury (57, 58).