Upregulation of Base Excision Repair Pathway, Kinetochore Metaphase Signaling Pathway, and SPINK1 Pancreatic Cancer Pathway; and NRAS, RRAS, RAC1, CD44, MAP2K2, R2RL1, and SMAD2 genesDownregulation of Phagosome Formation, and Calcium Signaling; and CCR and CXCR family genes. The gene discussed is SMAD2; the disease is pancreatic neoplasm.