IL6 and neoplasm: Examples include MSC-derived M2 macrophages, which express vascular endothelial growth factor (VEGF) in an NF-kB p65-dependent manner (93), MSC-derived IL-6 activating neutrophils, which in turn increases angiogenesis and tumor spread (84), and tumor-derived factor being able to polarize neutrophils to the N2 phenotype.