studied the TIME of 511 patients with non-small cell lung cancer (146 of whom had NACT) and discovered that following NACT, the infiltration of CTLs, CD20+ B cells, CD8+CD103+ and CD4+CD103+PD-1+TIM3- tissue memory T cells increased noticeably. The gene discussed is ITGAE; the disease is non-small cell lung carcinoma.