IKZF3 and Miyoshi myopathy: By contrast in MM, due to transcriptional regulation rewiring that is incompletely understood, IMiD-mediated IKZF1 and IKZF3 degradation causes sequential downregulation of MYC and IRF4 proteins, breaking the aberrant oncogenic proliferative drive of the MYC-IRF4 axis to induce cell cycle arrest and eventual apoptosis (26, 27).