However, recent studies have found that neutrophils can be mobilized to the liver by driving factors S100A8 and S100A9, forming neutrophil extracellular traps (NETs), resulting in the retention of tumor cells in the “traps”, further promoting the adhesion, proliferation, and invasion of tumor cells and the formation of liver metastasis (73, 74). The gene discussed is S100A9; the disease is neoplasm.