The elucidation of these mechanisms might provide specific therapeutic targets for GC liver metastasis, such as the inhibition of the shift from M1 to M2 type KCs, inhibition of the CXCR4/CXCR7-CXCL12 axis between liver and GC cells, and inhibition of the secretion of cytokines, such as VEGF, by liver resident cells. This evidence concerns the gene CXCL12 and gastric cancer.