In recent years, it has been confirmed that multiple signaling pathways are linked to the occurrence of GC liver metastasis, such as Wnt, nuclear factor kappaB (NF-κB), extracellular regulated kinase 1/2 (ERK1/2), transforming growth factor-β (TGF-β)/Smad, PI3K/AKT, Hippo-YAP pathway, etc. (Figure 1). This evidence concerns the gene MAPK3 and gastric cancer.