The effects of SFRE on the inhibition of the main bioenergetic pathways in NSCLC cells seemed to be on the bases of the observed effects on the inhibition of cell proliferation, as indicated by the quantification of the intracellular ATP content (Supplementary Figure 2A), and the upregulation of gene expression of apoptotic markers (Caspase-9 and DDIT3) (Supplementary Figure 2B). This evidence concerns the gene DDIT3 and non-small cell lung carcinoma.