Data suggest that CR group displayed a better control of lipid metabolism related inflammatory pathways at the systemic level, in accordance to the observed tendency, although not significant after multiple correction, towards the reduction of the expression of additional pro-inflammatory genes such as JAK1 (p=0.018), PATFR (p=0.013), CXCR1 (p=0.01), GPD2, and glycolytic genes LDHA (p=0.003) and IRS1(p=0.026), which have been associated to immunosuppression in cancer (46–49) (Supplementary Table 4). This evidence concerns the gene IRS1 and cancer.