We, in the present study, determined SGOL1 expression level in HCC and adjacent normal tissues in association with SIGLEC15, TIGIT, CD274, HAVCR2, PDCD1, CTLA4, LAG3, and PDCD1LG2 in light of the possible oncogenic involvement of SGOL1 in HCC. This evidence concerns the gene CD274 and hepatocellular carcinoma.