TP53 and familial pancreatic carcinoma: The upregulated pathways mainly contained cell cycle, P53 signaling pathway, pancreatic cancer, tumor pathway, Wnt signaling pathway, and the downregulated pathways mainly included linoleic acid metabolic pathway, complement, and coagulation cascade, cytochrome P450 on exogenous bio metabolism, degradation of valine, leucine, and isoleucine, and primary bile acid synthesis (Figure 5A).