Studies have also found that the VEGF signaling pathway is regulated by calcium dobesilate (CAD) to alleviate diabetes in mice with high energy diet (56), and gene encoding cyclooxygenase 2(COX2) regulates glucose and lipid metabolism by regulating VEGF signaling pathway in mice with obesity caused by high energy diet (57). The gene discussed is VEGFA; the disease is obesity due to melanocortin 4 receptor deficiency.