Inmany cancers, α-2,6-linked sialic acids are overexpressed,and dysregulation of this glycan is emerging as a crucial part ofcancer formation, metastasis, and immune recognition.4,5,7−9,29 miRNA are major regulators of the glycome, but theirrole in controlling α-2,6-linked sialic acid has not been well-studied.15−19,54 Our comprehensive analysis ofthe miRNA regulatory landscape for the α-2,6-linked sialylationenzymes ST6GAL1 and ST6GAL2, described herein, has revealed new potentiallinks between miRNA and the upregulation of α-2,6-linked sialosidesobserved in cancer. This evidence concerns the gene ST6GAL2 and cancer.