Interestingly, we found that a genetic reduction or a pharmacological inhibition of TACE activity in the PVN of HF rats not only reduced CSF TNF-α, an indicator of sTNF-α, but concomitantly reduced TNFR1 mRNA and increased TNFR2 mRNA expression, favoring the protective TNFR2-mediated effects of TNF-α. The gene discussed is ADAM17; the disease is hydrops fetalis.