Compared with HF + VEH rats, HF + TAPI-0 rats had significantly lower levels of TNF-α in CSF (Figure 8A), mRNA expression of TNF-α (Figure 8B), TNFR1 (Figure 8C), COX2 (Figure 8E), protein levels of p-NF-κB p65 (Figure 8F) and p-ERK1/2 (Figure 8H), and higher mRNA expression of TNFR2 (Figure 8D) and protein levels of IκB-α (Figure 8G) in the PVN. The gene discussed is PTGS2; the disease is hydrops fetalis.