As Yoda1-induced Piezo1 activation had been shown to modulate the expression of transglutaminase 2 (TG2) (Retailleau et al., 2015), and TG2 plays a critical role in vascular calcification (Johnson et al., 2008), next TG2 mRNA expression of Yoda1-, OM- and OMY-treated cells were compared to control HAoSMCs. The gene discussed is PIEZO1; the disease is ocular melanoma.