SKP2 and acute lymphoblastic leukemia: Moreover, it has been reported that Notch activation promotes the role of SKP2 in T-ALL, forming a Notch/SKP2/p27Kip1 forward feedback loop (Table 2) (Zhang et al., 2000; Barata et al., 2001; Dohda et al., 2007; Rodriguez et al., 2020).