As c-Cbl mutant protein can stimulate FLT3 signaling, we envisioned the existence of a c-Cbl, JAK2, and FLT3 signaling axis, regulating the development of AML (Figure 3) (Table 2) (Rathinam et al., 2010; Taylor et al., 2015). The gene discussed is FLT3; the disease is acute myeloid leukemia.