AKT1 and cancer: In cells, it is able to accumulate in and disorganize rafts by increasing PM thickness and fluidity, subsequently inhibiting the PI3K/Akt proliferation signaling pathway while promoting Fas death receptor recruitment and apoptosis of cancer cells (Ausili et al., 2008; Hac-Wydro et al., 2011; Castro et al., 2013; Mollinedo and Gajate 2015; Ausili et al., 2018) (Figure 5D).