A multivariable logistic regression model identified adenosine deaminase (OR = 1.0115, 95% CI: 1.0030–1.0201, p = 0.0080) and parasitemia (OR = 2.0700, 95% CI: 1.2584–3.4050, p = 0.0042) as factors associated with severe malaria. This evidence concerns the gene ADA and malaria.