Accumulating evidence showed that the activation of the Nrf2 signaling pathway was significantly inhibited in MPTP-induced mice (Lee et al., 2018; Mohamed et al., 2021), while inducing Nrf2 activation could mitigate the degeneration of dopaminergic neurons and provide neuroprotection for PD (Zhang et al., 2021). This evidence concerns the gene NFE2L2 and Parkinson disease.