Jafari et al. (2019) used BEV on the A549 cancer cell line and evaluated the expression profile of cytokines and chemokines. These BEV significantly upregulated the anti-inflammatory cytokines, including IL-10, TGF-β2, and IL-1Ra, and downregulated some of the pro-inflammatory cytokines including IL-6, TNF-α, and TNF-β (Jafari et al., 2019). This evidence concerns the gene TNF and cancer.